Non-Stim Pre Exercise Now with Nitrosigine (2023 V3)
Any time Glaxon broadcasts a brand new product launch, the business pays consideration – and no person watches extra carefully than the PricePlow content material crew.
The explanation for that is that Glaxon at all times comes up with one thing new. Whereas many different complement formulators are content material to combine and match time-tested standby elements, seemingly each Glaxon product both introduces shoppers to a new ingredient or places a brand new spin on an ingredient whose potential has not been absolutely explored.
Crucially, Glaxon’s modern approaches work. Right here at PricePlow, even we get overwhelmingly constructive suggestions from shoppers concerning the firm’s inventive components designs.
The large latest announcement from Glaxon is that they’re releasing the third iteration of Plasm Surge, a stim-free, pump targeted pre-workout. And this iteration brings Nutrition21’s patented powerhouse, Nitrosigine, to advertise nitric oxide manufacturing and take your coaching to a brand new degree.
True to type, Glaxon was on the bleeding fringe of a now-pervasive business development: shifting away from huge stimulant doses in pre-workouts. Plasm Surge was one of many first and greatest entries on this rising product class.
Plasm Surge’s V3 redesign focuses on boosting nitric oxide and ATP technology, which is thrilling to us as a result of we’ve been immersed within the scientific literature on this topic as of late. ATP-focused NO boosting will probably be one of many subsequent huge business developments, and seeing Glaxon assert itself as an early adopter reinforces that perception.
Let’s get into the small print of how this new components works… However first, test the PricePlow information and offers!
Word: Examine the label at every retailer to make sure that you’re getting the components you need.
Should you simply need the highlights, right here’s how the brand new components differs from the previous one.
And eventually, they elevated the dose of arginine (past Nitrosigine) and barely adjusted doses of different elements too.
In a single, 1-scoop (20 gram) serving of Plasm Surge V3 from Glaxon, you get the next:
L-Citrulline – 6,000 mg
Citrulline is an amino acid that packs a strong punch in terms of enhancing nitric oxide (NO) manufacturing.[1,2]
The up to date Glaxon Plasm Surge V3 Components. Comparisons to V1 and V2 are on the backside of this text.
Previously, arginine was the complement business’s go-to NO precursor, however latest years have seen citrulline exchange it because of the latter’s superior bioavailability.[3] Citrulline is simpler at boosting NO as a result of, not like arginine, it doesn’t fall prey to the primary cross impact, a phenomenon by which ingested substances are damaged down within the abdomen earlier than reaching the intestinal wall.[4-8]
That being stated, research present the mixture of citrulline and arginine is simpler than both ingredient alone[1,9,10] – and, luckily, we have now each of them in Glaxon Plasm Surge V3!
Citrulline’s upregulation of NO comes with quite a few advantages, corresponding to:
- Elevated oxygen uptake and top-end muscular energy[11]
- Elevated athletic endurance. In a single 2010 examine, excessive doses of citrulline led to a 50% improve in topics’ most bench press repetitions.[12]
- Considerably lowered post-workout muscle soreness – as much as 40% discount in severity[12]
Elevated blood circulation interprets to extra environment friendly nutrient and oxygen supply, in addition to quicker lactic acid clearance, which is essential for athletes since its accumulation results in post-exercise muscular fatigue and soreness.
As most of us know by now, when used alone, citrulline beats out arginine in terms of elevating nitric oxide ranges.[2] However…. wait till you see what occurs when arginine is added!
Beta-Alanine – 3,200 mg
Beta-alanine has an extended historical past of use as an ergogenic assist. – it’s been a mainstay because the starting of the dietary complement business.
When beta-alanine is mixed with L-histidine, the result’s carnosine, a dipeptide molecule that’s ample in muscle tissue. Carnosine’s perform in muscle tissue is to assist take away lactic acid, a waste product that causes muscular fatigue when it accumulates.[13]
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Thus, decreasing lactic acid accumulation, through beta-alanine supplementation, is a sensible strategy to enhancing athletic endurance.
Regardless of carnosine’s advantages, it’s higher to take carnosine precursors relatively than carnosine itself. The scenario is similar as that of citrulline versus arginine, with the precursor being extra orally bioavailable than the goal compound.
The bottleneck, in terms of carnosine manufacturing within the physique, is the quantity of beta-alanine obtainable to cells – beta-alanine is the rate-limiting issue.[14,15] Therefore, supplementing with beta-alanine is an virtually surefire strategy to stimulating carnosine manufacturing, particularly since histidine, the opposite needed precursor, is ample in widespread meals.
Two giant meta-analyses analyzing over 40 peer-reviewed papers on beta-alanine discovered that the compound is simplest for enhancing endurance throughout train classes performed at a sustained depth, between 30 seconds and 10 minutes.[13-20]
The three,200-milligram dose utilized in Glaxon Plasm Surge V3 is probably the most generally used and clinically validated by far.
A phrase concerning the beta-alanine tingles
Upon taking beta-alanine, most people expertise a tingling sensation of their higher physique. Though it’d really feel unusual for first-time customers, the scientific consensus is that this tingling is innocent, and that beta-alanine is protected for human consumption.[21]
L-Arginine – 2,000 mg
Arginine nitrate may seem to be an odd ingredient to indicate up in Glaxon Plasm Surge V3. In spite of everything, we stated earlier that oral arginine dietary supplements aren’t as efficient.[4-8]
Nevertheless, there’s an exception to this rule. As we talked about in passing, when mixed, arginine and citrulline outperform both ingredient taken alone in each people[9,10] and animals.[1]
With the improved arginine standing, we get improved nitric oxide ranges, higher blood circulation and circulation… and finally, higher efficiency![10]
The synergistic results of arginine and citrulline are one cause arginine hasn’t fallen utterly out of trend amongst savvy complement formulators.
The explanation this mixture works is that the presence of citrulline inhibits arginase, the enzyme accountable for breaking down arginine within the first cross impact we mentioned above. In consequence, extra arginine transits the intestine and is absorbed by the intestines,[5,6] thus resulting in improved arginine bioavailability.
By combining arginine and citrulline, you’re getting much more NO than you’d with citrulline alone, and thus higher impact sizes with all the advantages we mentioned within the citrulline part. However don’t fear, there’s much more arginine coming by means of Nitrosigine!
Astrolyte Electrolyte Mix (Fructooligosaccharides, Sodium Chloride, Magnesium Citrate, Potassium Citrate) – 1,770 mg
Glaxon’s in-house electrolyte mix, Astrolyte, is utilized in quite a bit of their merchandise,together with Specimen, Specimen GFY, Plasm Surge, and Tranquility.
Glaxon Astrolyte deliver hydrating electrolytes in model. On this article, we dig deeper into the added mineral absorption ingredient, fructooloigosaccharides.
Astrolyte is made up of electrolyte minerals — sodium chloride, potassium, and magnesium — that play a vital function in muscle contractions and athletic efficiency, cardiovascular well being, bone density, insulin sensitivity, glycemic management, and blood strain.[22-34]
These electrolytes are misplaced in sweat throughout intense exercises. So, when you’re working onerous, it’s essential to replenish them for optimum efficiency and restoration.
We love electrolytes, however the inclusion of fructooligosaccharides (FOS) is what actually makes Astrolyte stand out. FOS is a particular carbohydrate that enhances mineral bioavailability (corresponding to sodium, potassium, and magnesium), thereby multiplying the advantages related to electrolytes it’s stacked with.[35-38] FOS additionally has a prebiotic impact by nourishing the useful micro organism within the intestine.[39]
Lastly, due to FOS, Astrolyte is naturally candy — roughly 0.3 to 0.6 occasions as candy as sugar.[40,41] This helps enhance the flavour of Glaxon Plasm Surge V3.
For additional data on this outstanding ingredient, click on by to our full-length article on Glaxon Astrolyte: Hydrating Electrolytes That Do Extra.
Nitrosigine (Inositol-Stabilized Arginine Silicate) – 1,500 mg
Nitrosigine is among the most superior and efficient nitric oxide selling elements on the dietary complement market immediately — it’s a patented type of arginine mixed with inositol and silica.[42] You’ll see it on complement labels as inositol-stabilized arginine silicate, however in most analysis research, it’s known as ASI.
Nitrosigine vs. Different Nitric Oxide Components[43] Picture courtesy Nutrition21
In comparison with different elements like L-arginine, L-arginine AKG, L-citrulline, L-citrulline malate, and agmatine sulfate, in-vitro analysis confirmed that Nitrosigine can promote a higher enhance in NO.[44]
This type of arginine (ASI) stays intact for longer intervals of time, supporting higher blood ranges of arginine and nitric oxide.[21] Nitrosigine is each fast-acting and long-lasting, taking impact as quickly as half-hour after ingestion, with results lasting as much as six hours.[43,45]
Arginine, citrulline, and Nitrosigine?
Glaxon’s inclusion of Nitrosigine in Plasm Surge V3 is extraordinarily fascinating. To grasp why, we have to focus on the historical past of arginine, citrulline, and the event of Nitrosigine.
As we talked about earlier, plain arginine fell out of favor with complement formulators as a result of its low oral bioavailability.[5-8] That was the issue Nitrosigine was designed to resolve: Nutrition21 got down to construct a greater arginine, one that might be absorbed extra effectively by the human digestive tract and wouldn’t want huge doses.
Sure! Now we have a full 1.5g dose of Nitrosigine for long-lasting pumps, endurance, and even some focus results!
As we additionally stated, the arginine precursor, citrulline, is usually used to work round arginine’s bioavailability limitations.[2] Nevertheless, you want giant doses of citrulline to realize maximal results,[46,47] and people giant doses can result in GI misery.[48,49]
Right here’s why the inclusion of Nitrosigine is fascinating: It might ship clinically important outcomes at a lot smaller doses, which is often why Nitrosigine replaces arginine and citrulline in formulation.
What we virtually by no means see is arginine, citrulline, and Nitrosigine in the identical components!
Arginine is fairly efficient by itself, citrulline even moreso; and like we stated, the mixture of arginine and citrulline has synergistic results.[1,9,10] So, even simply with generic arginine and citrulline, Plasm Surge can be ready to ship a very good pump, particularly since they’re generously dosed.
Throw in a medical dose of Nitrosigine on prime of all that, and all bets are off. In comparison with the everyday product entry, Glaxon Plasm Surge V3 appears to be like to ship actually insane pumps.
Glaxon actually went huge on this one.
Nitrosigine analysis
A nitric oxide booster that improves cognition?! Sure – Nutrition21 handed round this beneficial infographic after the Nitrosigine cognition examine on wholesome younger adults was revealed.[50]
Based on one examine, a 1,500 milligram dose of Nitrosigine can improve flow-mediated dilation (FMD), a measure of arterial blood circulation, by 31%. Compared, an 8-gram dose of citrulline malate elevated FMD by 34%,[51] that means that Nitrosigine produced roughly the identical impact measurement at roughly 1/5th the dose!
Glaxon, after all, determined to take that examine and do each.
Nootropic results
NO boosters are sometimes mentioned within the context of maximizing bodily efficiency. Nevertheless, the cognitive results of optimized NO manufacturing are arguably simply as vital! The mind isn’t any much less affected by circulation than another organ, in spite of everything. Actually, it has a disproportionately excessive demand for oxygen, ketones, and glucose circulating in your bloodstream.
And that is the place Nitrosigine provides much more clinically-studied advantages to Plasm Surge V3 — it’s particularly efficient at enhancing cognitive efficiency.
- NO as a potent vasodilator may also improve blood circulation within the mind, which can have cognitive advantages. One examine discovered that when Nitrosigine is taken previous to strenuous train, it will probably forestall the short-term cognitive decline sometimes seen afterwards.[52,53] Its cognitive advantages could even work inside quarter-hour of taking it![52]
- Nitrosigine supplementation has additionally been proven to enhance multitasking in wholesome younger males, even those that hadn’t exercised just lately.[54]
- One other examine confirmed that wholesome adults taking Nitrosigine carried out higher on a right away reminiscence check than these taking a placebo.[50]
Sustaining peak cognitive efficiency is an important a part of dealing with difficult exercise routines and avoiding burnout earlier than reaching one’s objectives.
Nitrosigine use can doubtlessly result in a slight discount in blood strain. Picture courtesy Nutrition21
That’s why we see pre-workout formulation more and more counting on heavy nootropic help, and we are able to’t consider a greater ingredient than Nitrosigine to play this function in Glaxon Plasm Surge V3.
Should you’re all in favour of a extra in-depth dialogue of this superior ingredient, take a look at PricePlow’s earlier article on Nitrosigine titled “Nitrosigine: The Nitric Oxide Booster That Enhances Mind Operate“.
Amla (Phyllanthus emblica) [Fruit] Extract (Std. to 50% tannins as Capros) – 250 mg
Amla, a fruit tree with a wealthy historical past in Ayurvedic medication, can be acknowledged by two scientific names, Phyllanthus emblica and Emblica officinalis.
Its significance in East Asian tradition earned it the nickname “Indian gooseberry.” Amla has been used for hundreds of years to enhance cardiovascular well being and deal with circulatory problems.[55]
How amla upregulates nitric oxide (NO)
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Fashionable analysis largely helps conventional data about amla. Sure antioxidants current in Indian gooseberries have been discovered to enhance endothelial perform whereas additionally stopping platelet formation,[56] thereby decreasing the danger for severe cardiovascular occasions, corresponding to coronary heart assaults and blood clots.
In research performed on animals, amla has demonstrated a noteworthy anti-hypertensive impact brought on by its stimulation of endothelial nitric oxide synthase (eNOS), which produces NO in arteries.[57]
One cause amla can do that is due to gallic acid, a bioactive constituent that’s naturally ample in amla fruit[58]. Analysis reveals that gallic acid can forestall the oxidative degradation of eNOS, resulting in a bump in serum eNOS ranges and a corresponding improve in NO manufacturing.[59]
Gallic acid can be a major bioactive constituent in tea, a beverage that’s famend for its cardiovascular advantages.[60]
The connection between ATP and eNOS
Amla tree extracts are standardized for low molecular weight tannins (LMWTs). Some examples embrace emblicanin-A, emblicanin-B, punigluconin, and pedunculagin.[61]
When the physique metabolizes these tannins, they’re transformed into urolithins A, B, C, and D, all of which might considerably enhance mitochondrial perform.[62]
Epic stack incoming – combine Plasm Surge with Specimen Genesis!
Your mitochondria are accountable for producing mobile power within the type of adenosine triphosphate (ATP). Your physique makes use of ATP to do every little thing, so, unsurprisingly, ATP manufacturing is positively correlated with improved well being and athletic efficiency.[63,64]
That’s properly and good, however what does ATP need to do with NO and pumps, that are purported to be the main focus of Glaxon Plasm Surge V3?
Because it seems, the most recent analysis reveals that elevated ATP manufacturing can upregulate endothelial nitric oxide synthase (eNOS), improve manufacturing of nitric oxide (NO), and enhance arterial perform.[65] This occurs as a result of when purple blood cells, platelets, and endothelial cells launch ATP in response to stimuli, calcium is upregulated inside endothelial membranes, inflicting the translocation of eNOS into endothelial cells, the place it’s activated to provide NO.[65]
Right here is how one professional describes the method:
As soon as launched, ATP binds to purinergic (P2X and P2Y) receptors on endothelial cells. Binding ends in the endothelial cells releasing nitric oxide through endothelial nitric oxide synthase, prostacyclin, and endothelium-derived hyperpolarizing issue, all 3 of which have an effect on the graceful muscle of the vasculature through cyclic guanosine monophosphate, cyclic adenosine monophosphate, and hyperpolarization, respectively.[66]
Amla’s different advantages
Except for its function in ATP upregulation, urolithin B may also have anabolic results.[67]
Lastly, Amla extracts may also enhance cognitive efficiency.[68]
L-Glutathione Lowered (as Setria) – 200 mg
The varied iterations of Plasm Surge have lengthy included Setria, a trademarked type of the extremely bioavailable L-Glutathione. Glutathione (GSH), as most of us have in all probability heard by now, is an endogenous antioxidant (i.e. produced by your personal physique) that scavenges free radicals and protects cells from oxidative injury.
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Setria’s modern fermentation course of has enabled the manufacturing of a GSH that has been clinically confirmed to boost serum GSH ranges, making it simpler than generic GSH dietary supplements. Moreover its superior bioavailability, Setria is a well known standardized glutathione complement that’s been in Plasm Surge for some time.
Though your physique can produce GSH by itself, beneath sure circumstances it may be useful to produce it with exogenous GSH for the aim of enhancing well being and efficiency.[69]
For instance, Setria has been proven to help immune system functioning by enhancing detoxing and preventing oxidative stress,[70] making it a doubtlessly helpful complement for pathogenic an infection.
Might synergize with citrulline
Though it’s mostly utilized in well being and wellness dietary supplements, Setria is showing increasingly more in performance-focused formulation like Glaxon Plasm Surge V3 due to key cardiovascular advantages, like enhancing blood circulation and pumps when stacked with citrulline.[71,72]
Analysis has proven that combining Setria and L-citrulline can doubtlessly result in synergistic and sustained will increase in nitric oxide manufacturing.[71] Different analysis has discovered that this mixture may also result in synergistic will increase in lean muscle mass and muscular power in comparison with each citrulline malate and a placebo. Extra analysis is required to verify these findings.[72]
The Setria dose utilized in these research was 200 milligrams, the identical dose in Plasm Surge V3.[71]
AstraGin (Astragalus membranaceus and Panax Notoginseng) [Root] Extract – 25mg
In an effort to maximize bioavailability, Glaxon makes use of 25 milligrams of AstraGin in Plasma Surge.
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AstraGin is a patented proprietary mix of Astragalus membranaceus and Panax notoginseng root extracts from NuLiv Science.[73-77] Whereas it affords quite a few advantages, its principal benefit is a capability to boost bioavailability and nutrient absorption.
Preliminary research counsel that AstraGin can activate a number of transporters within the small gut, thus enhancing their uptake of vitamins, together with amino acids, creatine, and omega-3 fatty acids.
As a result of we’ve been speaking quite a bit about arginine’s poor oral bioavailability, it’s value mentioning {that a} 2017 examine demonstrated AstraGin considerably improves L-arginine absorption.[78] This clearly makes it a beneficial ingredient for the Glaxon Plasm Surge V3 components, which options one of many greatest arginine doses we’ve seen shortly.
Furthermore, some analysis signifies that AstraGin can help general intestine well being by preventing intestine irritation and enhancing the structural integrity of intestinal tissue.
Pyrroloquinoline Quinone (PQQ) – 5 mg
Fascinating: 20mg day by day PQQ supplementation supplies all types of cognitive and psychological advantages. We don’t have this a lot of a dose right here, however suppose we must be seeing PQQ extra typically!
Pyrroloquinoline quinone (PQQ) is a disodium salt that’s able to growing mitochondrial biogenesis,[79,80] the method by which the physique generates new mitochondria. PQQ does this by upregulating sirtuin 1 (SIRT1), an enzymatic protein with unimaginable advantages for well being and longevity.[79]
Larger mitochondrial density means extra ATP, which ends up in, as we’ve mentioned, NO upregulation, improved circulation, and higher oxygen utilization.[81]
PQQ’s results on circulation can really enhance cognition,[82] very similar to Nitrosigine. When taken over lengthy intervals of time, PQQ supplementation can result in reductions in perceived stress, elevated power ranges, and higher sleep high quality.[83]
Once more, the addition of PQQ is an indication that Glaxon supposed to use the ATP-NO connection to the fullest with this Plasm Surge redesign.
You will get it flavored or unflavored, in order that it makes stacking with the brand new Specimen Genesis simpler than ever:
For a stroll down reminiscence lane, let’s have a look at the earlier variations of Plasm Surge:
With Plasm Surge V3, Glaxon strikes an beautiful stability between the tried-and-true pre-workout fundamentals and modern new elements.
The amount of citrulline and arginine right here – and the magnitude of their synergistic results – is not like virtually the rest we’ve seen. Glaxon went all in on the standard NO-boosting pathway, including the trifecta from Nitrosigine, citrulline, and arginine.
On the identical time, it’s evident they’re maintaining abreast of business and analysis developments – with amla, glutathione, and PQQ, the inevitable conclusion that we’ve come to is that Glaxon has been studying quite a bit concerning the connection between ATP and NO.
Plasm Surge is a type of merchandise that simply retains getting higher and higher. Glaxon positively didn’t disappoint with its third iteration.
Word: Examine the label at every retailer to make sure that you’re getting the components you need.
This text was initially revealed on August 3, 2020 and up to date on Might 12, 2023.
